Effectiveness of Prenatal Testing

Effectiveness of Prenatal Testing

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Effectiveness of Prenatal Testing

Down syndrome detection rate, basing on the mother’s age, nuchal translucency scan (NT) and foetal heart rate (FHR) is 80%. The ultrasound test results combined with dual test increase the method sensitivity up to 95% and 5% of false discovery rate. The evaluation of additional markers: nasal bone, blood flow through tricuspid and ductus venosus increases the detection rate of Down syndrome up to 96% and 2.5% of false discovery rate. NIFTY and HARMONY tests have detectability of over 99%, and 1% or less of false discovery rate. Confirmation or exclusion of chromosomal aberrations in foetus (i.a. Down syndrome) is possible after invasive diagnostics. Invasive tests involve chorion biopsy, amniocentesis and percutaneous umbilical cord blood sampling.

These tests give 100% certainty as for the foetus karyotype.

Invasive tests carry the risk of miscarriage of no more than 1%.